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These conserved motifs are most likely involved in intra- and intermolecular interactions required for stabilization of the closed form and formation of the active signaling platform.
The seemingly conflicting results obtained by different groups on the size requirements of the toxic Aβ oligomer could be elegantly unified when a model is considered in which peptide oligomerization provides the necessary intermolecular interactions required to stabilize a toxic conformation that cannot be adopted by a monomer in isolation.
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This means that neither pseudoknots nor intermolecular interactions (which require more complicated grammars) are considered.
These interactions require extensive additional theoretical analysis.
At the same time, intermolecular interactions seem to be required to have httNT form stable α-helical structure.
The second pattern can be understood in the light of much stronger Π−Π stacking of the PTCDA molecules, leading to a stronger intermolecular interactions, and greater energies are required to disrupt these molecules from their bulk positions when compared to pentacene bulk.
Large positive scores often indicate critical functional residues, which may be active site residues or residues required for other intermolecular interactions.
The scores are shown as positive or negative integers, and large positive scores often indicate critical functional residues, which may be the active site residues or residues required for other intermolecular interactions.
A boiling temperature is required to break all intermolecular interactions present in the liquid.
However, at the lower temperatures there is insufficient time for the more extensive rearrangement of the chains required for development of the intermolecular interactions that would stabilize crystals of the isotactic blocks.
Compound 4 displays no emission bands at any temperature confirming that presence of intramolecular aurophilic interactions is not sufficient for emissive behaviour and that unsupported intermolecular aurophilic interactions are required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com