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Exact(15)
The hydrogen bonds facilitate the intermolecular interactions on the A-A′ interface.
The strong intermolecular interactions on the C-C′ interface in PKM2K422R may be difficult to disrupt by PEP to form an R-state conformation.
Another PKM2 activator, TEPP-46, enhances the intermolecular interactions on the A-A′ interface and favors an R-state conformation (Anastasiou et al., 2012).
Analyzing structure, they noticed that PKM2 K305Q loses the intermolecular interactions on the A-A′ interface, which leads to the failure to form tetramer.
A chemical, TEPP-46 can enhance the intermolecular interactions on the A-A′ interface and favor an R-state conformation to activate PKM2 (Anastasiou et al., 2012).
Regulation of the intermolecular interactions on the A-A′ or C-C′ interface plays an important role in conformational changes of PKM2.
Similar(45)
Here, we report on the intermolecular interactions of a Y-shaped molecule, 1,3,5-Tris 3,5-dibromophenyl benzene, with six Br-ligands studied using scanning tunneling microscopy (STM).
In this work, the effects of various dendrimer shells on the intermolecular interactions of oligo phenyleneethynylene)s (OPE) molecular wires in thin films have been studied.
The weakening of the intermolecular interaction on the surface prevents the reaching of fast saturation.
For spin-crossover nanosystems, the narrowing of hysteresis width by decreasing of the intermolecular interaction on surface is detected.
Interestingly, these dimers are formed with the loss of intermolecular interaction on the C-C′ interface, suggesting that regulation on this interface may be responsible for the switch from pyruvate kinase activity to protein kinase activity of PKM2.
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