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G-tracts can also participate in hybrid quadruplexes (HQ) formation, which are intermolecular forms of G-quadruplexes formed between non-template DNA and nascent mRNA [ 36].
Since the G-quadruplex monomer is expected to have a biological significance in the HIV-1 promoter, we used native gel analysis to determine how efficiently it is formed over dimers and tetramers, which are intermolecular forms of G-quadruplex that do not require multiple G runs.
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Intermolecular interaction energies for representative configurations of intermolecular complexes were analyzed using the supermolecular approach at the MP2/6-311+G∗ level, which resulted in substantial interaction strengths for all the three forms of intermolecular interactions.
Furthermore, a high-level quantum chemical analysis was performed to analyze contributions of each of the three forms of intermolecular interactions (i.e. hydrogen bonding, π π stacking interactions, and cation π interactions) to the overall binding force of the adenine moiety of ATP in proteins.
Furthermore, the occurrence of amyloid-like aggregates per se does not depend on forming intermolecular disulfide bonds, and multiple forms of such aggregates can be produced from SOD1.
For the first time, signals from pure intermolecular SQCs were selectively observed in forms of spectrum or image.
The full set of intermolecular interactions formed between the Compstatin analogs and C3c residues in Figure 3 are in agreement with the X-ray structure of W4A9 in complex with C3c and with all previous MD simulation studies in explicit water solvent using the CHARMM forcefield.
In the case of a positive polar environment (e.g. clean metal surface) and due to the energetic state, the functional groups of the resin interact with the metal surface in form of intermolecular bindings [16] resulting in a sufficient adhesion between metal and resin.
The larger K 11 value may instead indicate some form of intermolecular complex though no direct evidence yet exists for this in solution.
Stabilizing loops that are built around a folded domain could in some cases also be supported by 'loop-stabilizing intermolecular interactions in the form of homo- and hetero-oligomers.
On the basis of findings of Cho et al., it is plausible that this single intermolecular disulfide forms rapidly postlysis if NEM or sufficient reductant is not present.
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