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The structures obtained were refined with the PHENIX refinement package phenix.refine [33] where intermittent model building was performed by using COOT [34].
Similar gross structural alterations were observed in this intermittent model.
Simple continuous STEGH mirroring an intermittent model, however, has the potential to greatly increase the burden of work for the host community institutions.
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Whether such hallmarks can be seen in intermittent models is yet to be determined.
In line with this conclusion, the preclinical papers included in the Special Collection of PLoS ONE make use of chronic or intermittent models of stress [30], [42] [45].
The continuous and intermittent models were used in case the loss of PTEN resulted in a prolonged signal for muscle growth that was obscured in the continuous overload paradigm.
If the control is intermittent (Models 3 and 4), the orbits are composed by a combination of PD-on and PD-off flows and the switching function described above automatically selects an orbit along the stable manifold of the latter flow.
However, none of these simple intermittent models reproduced the antipersistent characteristics of the experimentally measured trajectories.
Our conclusion is that the simplest intermittent models were insufficient to fully reproduce the characteristics of our data.
DOI: http://dx.doi.org/10.7554/eLife.02230.022 10.7554/eLiFigure30.023 Figure 5 figure supplement 2. Temporal and spatial dependence of the asymmetry coefficient for the simple intermittent models.
While the simplest intermittent models were insufficient to fully reproduce the characteristics of our data, a slightly more sophisticated model involving intermittent diffusion and trapping replicated the behavior of c-Myc.
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