Their work on intermittent exposures for extension of oxygen tolerance and on a model for prediction of pulmonary oxygen toxicity based on pulmonary function are key documents in the development of standard operating procedures when breathing elevated pressures of oxygen.
The first pathway involves intense intermittent exposure on the trunk of individuals who have large numbers of banal naevi and have melanoma diagnosed at a relatively young age.
Intermittent exposures to high levels of biomass smoke can have effects on multiple aspects of human health, including exacerbation of asthma and cardiovascular disease and alterations in either pulmonary or systemic immunity.
The technique consists of intermittent exposures to hypoxic stimuli (3 5 times per day, lasting at least 5 6 min, and spaced at least by 5 6 min) repeated over 2 3 weeks.
We classified people with a childhood history of playing in the piles of waste rock outside the plant as the group with intense intermittent exposures to potentially high concentrations of asbestos fibers.
The resistant lines were obtained by intermittent exposure of the KBM-3 cells to the highest tolerated concentration of m-AMSA so that the culture would be repopulated only by the most resistant subpopulation after each exposure.
The A2780CR cell line was established by intermittent exposure of the parental A2780 cell line to stepwise, increasing concentrations of cisplatin up to a concentration of 8 μM over a period of approximately 9 months [ 46].
Penttinen et al. found in their study that the intermittent exposure of rats to HBO for 2 h daily at 2.5 atm resulted in hypertrophy of the cartilage and an increase in the rate of bone formation [ 10].
Long-term intermittent exposure of esophageal tissue to DCA such as that caused by duodenal reflux will therefore likely lead to sustained MAPK and AP-1 activation, as well as over-expression of COX-2.
Continued or intermittent exposure of men to DBPs in drinking water, even at levels below those that are acutely toxic to rodents, may have the potential to produce testicular toxicity as evidenced by altered semen quality.
16 While knowledge of the risk factors and pathogenesis remains sparse, it is postulated here that long-term exposure to the risk factors noted above, either singly or in combination, initiates the growth of glioma via a common pathway that involves prolonged intermittent exposure of the glia to endogenously synthesized retinoic acid.
