A recent study has reported that TCA cycle intermediates are used to synthesize glutamate, which is then decarboxylated to yield GABA in P. falciparum iRBCs [ 37].
Those intermediates are used to synthesize more complex biological molecules which cannot be labelled with fluorine-18 due to mechanistic reasons or are not stable enough to tolerate direct F-fluorination conditions.
To further investigate whether the increment of ROS levels contribute to the increased injury sensitivity to aminoglycosides of Bmi1−/− hair cells, the antioxidant N-acetylcysteine (NAC), which is a reduced glutathione (GSH) provider and a direct scavenger of reactive oxygen intermediates, was used to treat the neomycin-injured hair cells.
Proteins are made up of one or more polypeptide chains, each of which is composed of a sequence of amino acids, and the DNA sequence of a gene (through an RNA intermediate) is used to produce a specific amino acid sequence.
This common intermediate was used to prepare a series of compounds representing S-alkyl, S-aryl and S-benzyl substituted derivatives.
(C.2) No unmeasured confounding of the –Y relationship: for all and for all, where is a set of measured intermediate confounders, where "intermediate" is used to denote that may be affected by X (but not by M).
Scaled-down clearance validation studies were employed for several of the impurities for cases in which the impurity was below detectable levels in the manufacturing process intermediates, and were used to demonstrate the capacity and robustness of the process to provide additional clearance.
A +3 rating was used to indicate a very strong affirmative answer, −3 was used to indicate a very strong negative answer; intermediate scores were used to indicate degrees of affirmation.
All 5hmC sites in the intermediate stringency were used to assess chromosomal 5hmC density.
