Sentence examples for intermediates that induce from inspiring English sources

Inhibition of BER pathway leads to the accumulation of repair intermediates that induce energy depletion mediated cell death, and TMZ-induced cell death via BER inhibition is dependent on the availability of nicotinamide adenine dinucleotide (NAD+).

The biological role of p130Cas phosphorylation is also intriguing from the vantage point that a vast variety of extracellular matrix molecules, growth factors, hormones, and metabolic intermediates that induce tyrosine phosphorylation of p130Cas and subsequent coupling to Crk (Table 1).

Intestinal cytochrome P450s further metabolize aglycones to potentially reactive intermediates that induce severe endoplasmic reticulum stress or mitochondrial stress leading to cell death (Boelsterli et al., 2013).

In conclusion, we demonstrate that celastrol targets MRC complex I and induces ROS accumulation and that accumulated ROS act as the key intermediate that induces cell cycle arrest, inhibits HSP90 chaperone function, downregulates HSP90 client proteins, activates JNK and initiates apoptotic and necrotic cell death.

To test if the membrane precursors generated by starvation is a downstream effect of PI3K activation, we performed the lipidation assay with the 100K membrane and compared its sensitivity to PI3K inhibition as well as PI3P occlusion with the 25K membrane which contains the ER-Golgi intermediate compartment that induces LC3 lipidation in a PI3K-dependent manner (Ge et al., 2013).

What is especially striking is that two different protein expression patterns occur in these intermediates: that induced by contact with ECM proteins and that induced by OS media.

High resolution solution NMR structures were determined in SDS micelles at pH 5, conditions that induce an intermediate level of helicity in the peptides.

Between these extremes are pathogens that induce responses of intermediate cross-reactivity.

Herbs that inhibit CYPs such as CYP3A4 or that induce GSTs may have the potential to protect against chemical carcinogenesis since the mutagenic effects of carcinogens are often mediated through an excess of CYP-generated reactive intermediates.

The model predicts that studies of chronic inflammation will require an intermediate LPS dose that induces inflammation but does not cause saturation and extensive downregulation of TLR4 receptors.

We suggested that application of oxygen control during methanol feeding under fed-batch cultivation prevents the over-feeding of methanol and overaccumulation of toxic intermediates that could additionaly induce GSH biosynthesis [ 18].