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Nitric oxide and reactive oxygen intermediates play a crucial role in the pathogenesis of myoglobinuric acute renal failure (ARF).
Intermediates play a relevant role in the folding process; many diseases of genetic nature are in fact coupled with protein misfolding, which favours formation of stable inactive intermediate species of a protein.
Alternatively, could intermediates play a role in correct folding, even for proteins that apparently fold efficiently without them?
Nitric oxide, together with reactive oxygen intermediates, play a key role in the activation of disease resistance mechanisms (Delledonne et al. 1998).
The C3 (2pyruvatevand and PEP) and C4 (OAA and malate) intermediates play a critical role in the overall network organization.
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Therefore, to summarize: proinflammatory processes induced by accumulated lipid/cholesterols intermediates play an important initial role in AMD.
Some amino acids or metabolic intermediates play an important role in plant growth and developmental processes, as well as in the resistance of plants to a variety of stresses, including both biotic and abiotic stresses [ 44].
The dynamic equilibrium of fatty aldehydes, key intermediates, played a critical role in microbial alkanes production, due to the poor catalytic capability of aldehyde deformylating oxygenase (ADO).
The lithium/sulfur (Li/S) cell is a liquid electrochemical system, in which the dissolution of lithium polysulfide (PS, the series of the sulfur reduction intermediates) plays an essential role in the cell's performance.
Arg273 plays a key role in substrate affinity and His, by acting as a hydrogen bond donator/acceptor in the peptide intermediate, plays a critical role in the enzymatic reaction [ 26].
Kinetic studies suggested that the formation of the enolate intermediate played an important role in inhibition.
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