Sentence examples for intermediates of which from inspiring English sources

Moreover, the reversible interconversion of serine and glycine is directly coupled to one-carbon metabolism, intermediates of which are considered important targets to treat cardiovascular disease (Fig 1; see below) (Locasale, 2013).

There have also been precedents for CH iPr) metalation of 4-isopropylpyridine with lithium, sodium, or potassium metal, the intermediates of which were used to carry out side-chain alkenylation and aralkylation reactions with conjugated dienes or styrenes.

Interestingly, DHFR not only regenerates active BH4 from oxidized inactive BH2 but is also a key enzyme in folate and one-carbon metabolism, intermediates of which in turn regulate BH4 biosynthesis and are associated with cardiovascular disease (Humphrey et al, 2008).

In Arabidopsis ∼200 DSBs form per meiosis and proceed to form strand invasion intermediates, of which ∼10 are repaired as crossovers, with the excess being repaired as non-crossovers, or via intersister recombination (Giraut et al., 2011; Ferdous et al., 2012; Lu et al., 2012; Sun et al., 2012; Yang et al., 2012; Drouaud et al., 2013; Wijnker et al., 2013; Qi et al., 2014).

According to the experimental results, complex 1 undergoes in DMF multistep reduction via a number of intermediates, two of which were detected using in situ EPR spectroscopy.

This leaves us to consider Rxn 2 which results into many intermediates some of which were detected experimentally in our studies.

Gluconeogenesis converts pyruvate to glucose-6-phosphate through a series of intermediates, many of which are shared with glycolysis.

Many of these assembly factors bind and dissociate at defined times giving rise to discrete assembly intermediates, some of which have been partially characterized with regards to their protein and RNA composition.

Fe-TAML catalyst processes also degrade organophosphorus pesticides as well as their toxic degradation intermediates, some of which have been implicated as endocrine disruptors, says Horwitz.

Instead, it is suggested that the destruction of chloroplasts may trigger the generation of short-lived reactive oxygen species (ROS) from limited amounts of tetrapyrrole intermediates, several of which are phototoxic (Mochizuki et al, 2008; Moulin et al, 2008).

Importantly, it is the premature activation of this pathway that induces deleterious crossovers, as its action in G2/M on mitotic recombination intermediates, most of which would have involved the sister chromatid, is expected to be genetically silent.