These results supports the hypothesis that alternate forms of the XA21 proteins are functional and suggest that XA21cp may also serve a critical role in immunity rather than existing simply as an intermediate of cellular proteolysis.
Taking an animal model approach to exploring possible metabolic contributions to the pathogenesis of autistic-like behavior, MacFabe et al. investigated the effects of propionic acid (PPA), a short chain fatty acid and an important intermediate of cellular metabolism, on behavior, electrographic activity, neuropathology, and oxidative stress in rats exposed to intraventricular PPA [23].
MG is a reactive intermediate of cellular metabolism, present ubiquitously in all cells.
Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer's disease.
The measured molecules are often referred to as metabolites as many of them act as educts, products and intermediates of the cellular metabolism.
Recent advances are indicative of the requirement of an intermediate level of cellular tension for MSC self-renewal [5,15,16].
These pioneering authors recognized that although many conditions resulted in acute lung injury, all evolved from initial permeability edema through an intermediate stage of cellular proliferation to its resolution by healing or fibrosis.
This enzyme is involved in energy production and siphoning of various intermediates for cellular metabolism [ 41].
The approach considered in this study concentrates on a conceptualization of GRNs that ignores intricate intermediate biological processes of cellular gene regulation, such as splicing, capping, translation, binding and unbinding [ 4].
Moreover, recapitulation of a particular differentiation pathway in vitro would provide an accessible model to study the formation and subsequent differentiation of cellular intermediates.
