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As homo sapiens aldehyde dehydrogenase 1 family member A1 (ALDH-1) is a known detoxification enzyme and inactivates CPA intermediates, expression levels were measured in HUH-REISO and in HUH-PAS during therapy.
Effects of RTK and downstream inhibitors/shRNAs were assessed by measuring mesothelioma cell viability/growth, apoptosis, activation of signalling intermediates, expression of cell-cycle checkpoints, and cell-cycle alterations.
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The YFP+ cells show an intermediate expression of CD11c, the classical marker expressed on dendritic cells (DCs).
In all tissues, a near bell-shaped curve was observed, where genes with intermediate expression levels were higher in 5mC than weakly or highly expressed genes.
Solving for yields the intermediate expression (16).
Exhausted T cells with intermediate expression of PD-1 (PD-1int) can be reinvigorated by blockade of the PD-1 pathway, whereas those with high expression of PD-1 (PD-1high cells) cannot [163, 164].
Group 5 showed intermediate expression of most traits (Table 3).
Nine of 21 lSSc-NoPAH samples clustered on the same branch and showed intermediate expression levels.
The EGFR-cocluster class showed intermediate expression levels of Proneural and Mesenchymal signature genes.
SW480 and DLD-1 cells showed similar, intermediate expression (Fig. 2A).
Conversely, MDMs displayed high expression of CD14 and little expression of CD1a and the same intermediate expression of HLA-DR.
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