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Concentrations of TCA intermediates change within seconds and minutes (for instance Acetyl-CoA in Figure 4).
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GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
Analyzing Radical and Intermediating Change.
Intermediating change is more common than radical industry evolution.
The core activities of industries on an intermediating change trajectory are threatened.
Take the example of auto dealerships, which are on an intermediating change trajectory.
Intermediating change is occurring in auto dealerships, for example, for a number of reasons.
Managing a company in an industry that is experiencing intermediating change is extraordinarily difficult.
During the 1980s and 1990s, approximately 32% of U.S. industries went through some form of intermediating change.
The challenge under intermediating change is to find ways to preserve knowledge, brand capital, and other valuable assets while fundamentally changing relationships with customers and with suppliers.
Intermediating change occurs when core activities are threatened with obsolescence customer and supplier relationships are stretched and fragile while core assets retain their capacity to create value.
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