Sentence examples for intermediate through the from inspiring English sources

On the contrary, details of the electron transfer pathway from NADPH to the postulated 2-iminoglutarate intermediate through the enzyme flavin co-factors and [Fe S] clusters are largely indirect.

NA synthase (NAS) catalyzes the trimerization of S-adenosyl Met (SAM) to NA (Higuchi et al. 1994, 1999), which is then converted to a 3′-keto intermediate through the transfer of an amino group using NA aminotransferase (NAAT) (Kanazawa et al. 1995).

One hypothesis is that the W motif promotes entry of the polyketide intermediate through the southeast opening of the active site groove in A-type KR, yielding a product with an l orientation.

At present it is not clear whether the compounds L29 and L1 can also bind to the catalytic histidine: although a doubly bound adduct, with alkylation of the acyl enzyme intermediate through the active site His, has been described for some β-lactams, 23) the chemical structures of L29 and L1 suggest this to be unlikely.

In this case, it is feasible that the formation of the [H2Bpin]− anion will facilitate the assembly of a bimetallic intermediate through the augmentation of the Lewis basicity of the pinacolate oxygen centers and a consequently enhanced facility for intermolecular Mg-O coordination.

All of the above N-de-ethylation processes also produced a parallel series of N-de-hydroxyethylated intermediates through the hydroxylation of the N-ethyl group.

More fundamentally, the support effect appears to correlate with the electronegativity of the support cation, which is proposed to have influence upon the rate of methoxy decomposition through hydride abstraction and on the steady-state equilibrium adsorption capacity of methanol to surface methoxy intermediates through the basicity of the bridging V O support bond (the adsorption site).

We speculate that the frameshift mutation alters the substrate specificity of MmgD in favor of citrate, thus increasing the flux of lactate-derived intermediates through the tricarboxylic acid cycle.

Substrate channeling has many advantages over the free diffusion of reaction intermediates through the bulk solvent: Isolating intermediates from competing reactions (3 ).

Under hyperglycaemic conditions, the primary amino group of protein reacts nonenzymatically with the carbonyl group of glucose forming Schiff base intermediates through the Maillard reaction.

These results suggest that the signaling cascades of the P4-repressed snail/EMT in MB468 cells are mainly intermediated through the EGFR and PI3K/Akt pathways.