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Use of rats of various strains in previous studies makes interstudy comparison difficult when trying to design an appropriate model control that would yield intermediate survival.
The histological subtype is also related to prognosis since the epithelioid histotype presents the best survival time, while the sarcomatoid histotype presents the worst prognosis, whereas mixed histotypes show intermediate survival time.
We also simulated at an intermediate survival level of 0.8, which is a high but realistic probability of individual mortality (IJF, unpublished data).
The Japanese and New Zealand strains were significantly excluded from the most susceptible cluster and enriched in the intermediate survival cluster (p = 0.0001 and p = 0.0006, respectively).
However, distinction of an intermediate survival group formed by tumor cells with limited self-renewal properties indicates that the degree of immaturity of these cells may provide a pertinent novel model for the stratification of pediatric brain tumor prognosis.
This explanation is not fully satisfactory, since embryos from infected mothers and cured fathers produced embryos with intermediate survival, despite the fact that all of these male embryos carried Wolbachia.
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At intermediate emigrant survival the size threshold for smolting is increased when freshwater survival is high and it is conceivable that a few slow-growing fish might not reach this size threshold as YOY.
ER-positive LN negative cancers have the best outcome, and ER-positive LN positive cases showed an intermediate overall survival, while TN and HER2 positive nonluminal types showed the shortest survival, as already reported [ 2, 3, 11, 14, 33].
According to a meta-analysis of inbreeding depression in various fitness components, the magnitude of inbreeding depression was highest in growth (plant biomass), lowest in fertility (pollen and ovule traits) and intermediate in survival (Angeloni et al., 2011), which is consistent with our results.
The remaining six strains exhibited intermediate median survival times.
Patients with one favourable genotype showed an intermediate median survival time of 10.2 months (95% CI: 6.8, 15.3) (P<0.001).
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