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Although this method is formally exact we note that noise estimators may be strongly biased for small to intermediate sample sizes [ 24].
At the 0.05 significance level, SWRF* performed statistically significantly better than SURF* at intermediate sample sizes (400 and 800) and intermediate to higher heritabilities (0.2, 0.3 and 0.4 at MAF = 0.2 and 0.1, 0.2, 0.3 and 0.4 at MAF = 0.4).
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The present study is intermediate in sample size between these two studies, which included 74 and 484 cases, respectively.
At intermediate heritabilities and sample sizes, SWRF* and SURF* performed significantly better than ReliefF, and SWRF* outperformed SURF*.
When alleles are found at intermediate frequencies, required sample sizes are largely independent of p. The analytic theory used to generate sample sizes was verified by MATLAB simulations.
To avoid only detecting associations with intermediate frequency alleles, larger sample sizes are needed.
Since sample sizes for intermediate Tanner stages (2, 3, and 4) were small, we assessed community differences between the stages with the largest numbers of subjects (Tanner stage 1 versus 5).
Here again, both size and shape of the NCs were basically preserved (see Figure 3 a, Figure S8a d, and S5c portraying additional images of intermediate samples and the size distribution histogram of the 24 h sample).
Larger studies tended to achieve publication in higher than intermediate or lower impact journals (p = 2.99×10−7) and articles from North America, Europe & Australasia had larger sample sizes than those from Asia (p = 2.21×10−6).
Based on the results, minimum sample sizes required to make the boundary conditions effects' negligible are recommended for common asphalt binders indented at intermediate temperatures.
Perhaps with larger sample sizes.
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