GENII operates by using natural scene statistic models to identify distortion, to perceptually optimize the distortion parameter(s), to assess the quality of the intermediate repaired images, and to perceptually optimize the repair processes.
Thus, ssDNA is a common intermediate in DSB repair, nucleotide excision repair, recombination repair and at collapsed replication forks and is believed to have a key function in the DNA damage response (Lydall and Weinert, 1995; Lee et al, 1998; Pang et al, 2003).
Likewise, the relative amounts of the intermediates and repair products formed in each case were also estimated (Table 3A C).
It results from an imbalance between the production of ROS and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage.
Furthermore, gaps or nicks in only one of the two strands resulting from intermediates of repair of base and nucleotide damage will be transformed into DSBs when met by a replication fork.
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage.
Likewise, while the effects of knocking down various BER and MMR components, as well as the ATR and PCNA knockdowns distinguish the T/G- and U/G-repair intermediates, the mechanistic relationships between these pathways or factors, and the properties of the T/G repair intermediate that distinguish it from the U/G intermediate are not clear.
If failed replication intermediates are repaired rather than degraded, the opportunity may arise to create recombinant mtDNA molecules [ 54].
It has been hypothesized that differences in susceptibility to carcinogens result from an individual's ability to form genotoxic intermediates, to detoxify these intermediates, and to repair damaged DNA.
