Of most importance, we introduced an intermediate distractor question that was prone to induce frustrating and unnecessary checking on trials where no correct answer was possible.
In KR2, an equilibrium between L and M had been suggested, but we find that the intermediate in question arises after M, rather than before as L would.
The reversed polarity of the hairpin intermediate begs the question as to whether any elements of the Tn5/Tn10 base flipping mechanism are conserved in these enzymes [3], [25].
Upon reductive cleavage and generation of the dAdo intermediate, the critical question becomes how the reactivity of this species is controlled within the active site environment.
The ability of DNA polymerases to bind to and to extend a misaligned intermediate raises the question of how the formation of misalignment is initiated— that is, how and when strand slippage occurs during a polymerization cycle.
The implications of the proposed existence of onset rivalry raises questions about intermediate processes like flash suppression [21] or continual flash suppression [22] which occur when one image is presented continually while the other image is intermittently and repetitively flashed on for brief presentations.
Steiner [ 1] identifies three key questions for intermediate care research: 1) Which services are best for which patients at which point? 2) Which professionals should be involved, doing what at which point? 3) What is the bottom line financially?
The find still leaves open an important question about intermediate black holes.
Computational modelling has a vital role to play in these developments: unstable species such as transition states and reaction intermediates are crucial to questions of reactivity, but cannot be studied directly by experiment in systems as complex as enzymes.
We postulate that these gene products could function to carboxylate naphthalene, though the requirement of these enzymes for a phosphorylated intermediate would call into question whether these carboxylases could carboxylate naphthalene.
