Sentence examples for intermediate necessary from inspiring English sources

If a metabolic reaction is the only source of an essential metabolite (i.e. an essential intermediate necessary for the biosynthesis of biomass components), strategies were investigated to supply the essential metabolite from other sources within the metabolic network (e.g. another compartment).

Many valuable compounds, or the intermediates necessary for their biosynthesis, prove deleterious at the desired production concentrations.

The molecular intermediates necessary for engulfment during involution remain largely uncharacterized.

In addition to the metabolism of pentose, the non-oxidative PPP allows the production of intermediates necessary for nucleic acid synthesis.

This metabolic switch emphasizes the production of intermediates necessary for tumor growth and division and has been shown to be regulated by oncogenes and tumor suppressor genes in a number of key cancer growth pathways [ 18].

Interestingly, the carbamate protected compound 5p was significantly less cytotoxic than agent 5c, supporting the hypothesis that loss of HCl and formation of a spiro[2,5]cyclopropylcyclohexadienone intermediate is necessary for biological activity.

Quinonoide compounds, derived from hydroquinones are agents of oxidative stress and have a high toxic potential (Monks et al. 1992; Kappus 1987), which is why a rapid further metabolization of this intermediate is necessary to minimize exposure time and thus to avoid damage to the cell.

They constitute an excellent breeding place for snails, the intermediate hosts necessary for completion of the Schistosoma life cycle.

Cellular metabolism is also recognized as a canonical biological transport system and its bow-tie structure [10] has been recognized to be compatible with the categorization of metabolites into a variety of nutrient inputs that are transformed into intermediate metabolites necessary to the biosynthesis of final compounds.

Significantly, transplant experiments indicate that a novel signaling interaction between paraxial and intermediate mesoderm necessary for specifying primitive red blood cell fate is missing in spt mutants [ 22].

One framework is ' compound-filling framework' (Fig. 1B), which predicts pathways by hypothesizing intermediate compounds necessary between the source and target compounds.