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However, there is also an unfavorable regime of intermediate interactions where the genetic response is prohibitively slow.
In contrast, Ccnd1 is connected to T0901317 through a single indirect association involving multiple intermediate interactions.
Figure 4 shows the second and third order intermediate interactions obtained from the multiplication of the Binary matrix (see additional file 1 for the binary matrix of proteins used in this study).
In many biochemical networks, where dynamics of the intermediate interactions of different species (proteins) and molecular complexes are largely unknown, screening plays a significant role in the classification of dynamics-dependent network behavior.
This behavior is consistent with stronger physical interactions among P++ bacteria due to their high-pilus density, lower interactions among P+ bacteria due to lower pilus density, and intermediate interactions at the interface between P++ red and P+ green.
Together with this information, we can screen the network for largely unknown dynamics of the intermediate interactions and classify solutions according to a model's ability to meet specific performance objectives.
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Finally, co-regulation has been defined as an intermediate interaction between government and businesses (Palzer and Scheuer 2003).
For intermediate interaction strengths (but stronger than the tunnelling couplings), repulsively-bound pair processes have been shown to dominate the dynamics and single-particle-like dynamics can be recovered for the pair [10, 60, 61].
Some authors consider them commensals more than ectoparasites (Gelder 1999; Edgerton et al. 2002; Oberkofler et al. 2002; Quaglio et al. 2006), and their association with crayfish has recently been indicated as a cleaning symbiosis, that is, an intermediate interaction between mutualism and parasitism (Brown et al. 2012; Farrell et al. 2014).
Further, this weighting scheme improves community cohesiveness in settings where and indirect interaction may exhibit significant differential expression, but the intermediate interaction is non-significant.
The authors conclude that the DC-mediated NK cell activation was likely to be through an intermediate interaction of DCs with CD4+ T cells rather than a direction effect on the NK cells.
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