Deep understanding and investigation of patents of innovative drugs, in particular their chemical entity, polymorphism, manufacture, intermediates, formulations and indications may be useful for patent innovation and protect the interests of products on markets.
The very rapid-acting and long-acting insulin analogues have not been shown to lower A1C levels more effectively than the older, rapid-acting or intermediate-acting formulations (71– 71).
In this study, the roll compaction of an intermediate drug load formulation was performed using horizontally and vertically force fed roll compactors.
The selective hydrogenation of methyl oleate into oleyl alcohol, intermediate in the formulation of surfactant agents, is carried out over bimetallic catalysts containing cobalt and tin.
A coupled physical biogeochemical 1D model (BFM POM 1D) with an intermediate complexity benthic formulation was used to carry out sensitivity tests on the coupling parameters (sedimentation and diffusion at the sediment water interface).
However, pressure from competition in the chemical industry led UCIL to implement "backward integration" – the manufacture of raw materials and intermediate products for formulation of the final product within one facility.
The intermediate MW HA formulation GO-ON was not inferior to the reference low MW preparation Hyalgan on the WOMAC pain subscale score, but was also statistically superior on this primary and on most of the secondary outcomes as predetermined by the statistical analysis plan.
Enrolled subjects were men or women aged 35 70 years, with type 2 diabetes for >6 months and <10 years, treated either with a stable dose of metformin with or without sulfonylureas or treated solely with a long- or intermediate-acting insulin formulation (insulin glargine, insulin detemir, or NPH insulin) with or without a stable dose of metformin for at least 3 months.
Lastly, poloxamer 407 prepared formulations showed intermediate results of viscosity.
Formulations with intermediate proportions of TA (0.8 g/100 g) were shown to produce the best compatibilising effect.
