Sentence examples for intermediate endpoint from inspiring English sources

This information can then be used to improve the design of prospective studies, and of clinical intervention trials that use ACF as an intermediate endpoint.

A decline in prostate-specific antigen (PSA) is widely used to monitor treatment response, but is not validated as an intermediate endpoint for overall survival (OS).

Another strategy for increasing the efficiency of breast cancer prevention trials is the validation of intermediate endpoint biomarkers [ 3] to secure validated intermediate endpoint biomarkers (VIEBs).

Therefore, the postulated effect between the process and an intermediate endpoint of SDM could be confirmed.

With this in mind screening patterns may be used as an acceptable intermediate endpoint.

Short-term change in Ki67 has been validated as an intermediate endpoint of clinical benefit from AIs [ 27].

To explore the predictors of intermediate endpoints of cervical cancer in 500 women living in Porto Alegre.

Composite measures comprising patient reported outcomes and intermediate endpoints such as PFS may be the solution and should be investigated further.

These latter measures will provide data on the efficacy of the intervention on intermediate endpoints linked to the primary outcome of interest.

The Food and Drug Administration would consider assessments of a device's effect on intermediate endpoints that, when improving in a congruent fashion, are reasonably likely to predict clinical benefit.

We recommend that basic science and population trials be developed specifically for older hosts with intermediate endpoints of relevance to this group, including cognitive function and trajectories of frailty.