However, the possible CFRP intermediate debonding may drastically reduce the reinforced steel beam strength against fatigue crack propagation.
For large populations, the probability that deleterious intermediates will fix declines drastically, and successful double mutants will instead arise on the unfixed single-mutant background in a process known as stochastic tunneling [ 16].
Although the ductility and toughness of these composites at ambient temperatures is improved by the B doping, those of Ni3Al composites drastically decrease at intermediate temperatures due to dynamic oxygen embrittlement, deterioration of grain boundary cohesion and unique behavior of dislocations.
In contrast to the case for PRPP, the intracellular levels and C incorporation into the pyrimidine biosynthetic intermediates dihydroorotate and orotate decreased drastically after feruloyl amide and coumaroyl amide treatment (Fig. 3), which suggested inhibition of a biosynthetic step upstream of dihydroorotate.
In this way SISMA drastically reduces the number of intermediate structured motifs generated and usually avoids out-of-memory failures at the price of a moderate slowdown (see the Computational cost section).
As the opening of the main expansion valve was decreased, the performance of the VI system generally got better but the system had much restricted intermediate pressure ratio in which the performance was drastically decreased.
Exact intermediate patterns are rare (sometimes even unique) and differ drastically from the majority of patterns.
An exception are the transcripts of one GLDP, one GLDH and one SHM isoform which are drastically down-regulated also in the C3 C4 intermediate species.
In the Old Kingdom many women served as priests, but their presence in clergies declined drastically in the Middle Kingdom before increasing in the Third Intermediate Period.
However, an a priori distinction between reversible and irreversible reactions may become problematic under extreme conditions, e.g. depletion of substrates or accumulation of intermediates due to inhibition of enzymes, where metabolite concentrations may drastically change thus allowing to reverse reactions that are normally designated to be irreversible.
