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Patients with anti-topo I had an intermediate disease duration (5·1 years).
Centrum semiovale and corpus callosum were further reduced in bulk compared to cases with an intermediate disease duration, and the entire ventricular system was extensively dilated.
In three studies of patients with an intermediate disease duration of 2.5, 2.8 and 3.5 years, the levels of these cytokines were still increased [ 88- 90].
Three cases (numbers 2, 14, 17) were of intermediate disease duration and three cases (numbers 5, 20, 21) were of long disease duration.
Tau-positive astrocytic inclusions were present in the cerebral cortex of all subjects with an intermediate disease duration, with tufted astrocytes and astrocytic plaques being present in subjects 2 and 17 (Figs. 8G and 9B).
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The average disease duration was 12.7±10.4 (1–41) years.
On average, disease duration was 20 years.
Cases with an atypical PSP-like syndrome were of either short (1 year) or intermediate (6 years) disease duration.
There was no significant difference in the initial level of serum MMP-3 among patients with short, intermediate or long disease duration [247 (50 ~ 352) ng/ml vs 159 63 ~ 2911) ng/ml vs 279 (41 ~ 440) ng/ml, P = 0.875].
There was also no significant difference in the percentage of patients with elevated serum MMP-3 among short, intermediate or long disease duration groups (60%% vs 78%% vs 68%%, P = 0.593).
In a study with intermediate CRPS patients (disease duration 2.8 ± 1.4 years), we found a significant increase in IL-6, TNF-α and ET-1 levels in blister fluid in the CRPS extremity versus the contralateral extremity [ 89].
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