Collapse of this intermediate causes His to donate its proton to ACPs.
Therefore, it would be expected that the introduction of a third hydroxyl (3,4,5-trihydroxycinnamic acid), a methoxyl (sinapic acid), or a bromide (5-bromocaffeic and 5-bromoferulic acids) substituent in position-5 of the aromatic ring of the cinnamic acid could affect the formation and/or stabilization of the radical intermediate causing a decrease of the oxidation potential.
Rearrangement of the membrane-proximal stem, from a conformation buried in the outer leaflet of the viral membrane to one that stabilizes the inter-protomer trimer interface, can then 'zip' the trimer together and induce collapse of the extended intermediate, causing the transmembrane anchors to approach the trimer-clustered fusion loops (Pangerl et al., 2011; Klein et al., 2013).
The accumulation of glycolytic intermediates caused by glycolytic inhibition channels glucose flux into the PPP.
Thus, it should be possible to determine the rates of appearance and disappearance of reaction intermediates caused by rearrangements of the side chains in the NBP of the L415G variant.
To determine if stable unfolding intermediates cause low-ATP stalling, we designed and characterized circularly permuted GFP variants.
Phytochemical injury is generated using a photosensitizing dye such as rose bengal, which produces reactive oxygen intermediates, causing photo excitation, leading to oxidative damage of the vessel wall and subsequent thrombus formation.
During tumor initiation, aneuploidy may arise via polyploidization where unstable tetraploid intermediates cause further chromosomal abnormalities including chromosomal gains, losses and translocations [3], [4].
Chl intermediates cause photo-oxidative damage to the cell.
It is thought that twinkle mutations result in an accumulation of replication intermediates, causing replication stalling and eventually depletion.
Usually, TCA intermediates cause the suppression of pyruvate kinase activity, the main modulating enzyme in carbohydrate catabolism (Lin et al. 1989).
