The final candidate area for a transmitter consists of the intersection of the intermediate candidate areas computed over all receiver subsets.
Each receiver subset computes an intermediate candidate area as the intersection of the hyperbolic areas constructed from all receiver pair combinations within that subset.
The r-pair set algorithm groups receivers in subsets of size, computes intermediate candidate areas for each subset using the all-pairs approach within the subset, and yields an ultimate candidate area for a transmitter as the intersection of the receiver subset intermediate candidate areas.
Based on these observations, we propose that Neu1 might be an intermediate candidate connecting the Snail-MMP signaling axis in tumor neovascularization and in promoting the growth and spread of human ovarian cancer.
After candidate gene selection and exclusion of patients with degraded or missing samples at intermediate time points, candidate genes were validated in the total cohort (n = 71 patients; n = 517 samples) by quantitative RT-PCR.
As etoposide causes DNA damage, an obvious candidate intermediate is p53, the main DNA damage sensor.
Possible reasons for the failure include poor choice of ρ, insufficient N, and nonexistence of candidate intermediate reaction rates that satisfy the update criterion.
(iii) Associations found in GWAS with clinical end points are enriched in GIMs, and the related metabotypes are candidate intermediate traits on the pathway to the disease [for details on the concept of the intermediate phenotype, see (5)].
This effect was confirmed by non-parametric results that had a medium effect size (U = 313.5, p = .015, r = −0.3), and can thus be interpreted as preliminary evidence for the utility of the Hyperactivity factor as a candidate intermediate phenotype for ADHD.
Overall, these numbers clearly indicate the limited resolution of QTL data and emphasize the need for prioritization (See Table 2).> -wrap-foot>> -wraAsfoot> aAs intermediate step in candidate gene prioritization, traits and biological processes (BPs) were associated using overrepresentation of biological processes found for genes connected with each trait in the rice Gramene QTL compendium.
