UV exposure at 365 nm (see the complete protocol in the ESI †) leads to the regeneration of the original quadruplex ligand PDS through the formation of an intermediate attributed to a 2-nitrosobenzyl hemiaminal derivative (see Fig. S1, ESI †).
This approach can be used to justify process parameter and equipment flexibility in the context of a pharmaceutical design space based on a proven acceptable range of peak pressures, or achieving target intermediate quality attributes, such as ribbon density.
Particle swarm optimization- (PSO-) based least square support vector machines (LS-SVM) and partial least squares (PLS) models were developed for quantitative analysis of the critical intermediate quality attributes: the soluble solid content (SSC) and concentrations of danshensu (DSS), protocatechuic aldehyde (PA), hydroxysafflor yellow A (HSYA) and salvianolic acid B (SAB).
Neurons are connected by "synapses" and the ones in the intermediate layers attribute "weights" to each variable, based on the strength of the connection.
The intermediate response is attributed to the interplay between various characteristics of the power spectrum and "ohmic equilibration layer thickness".
Figure 3 shows the evolution over time of concentrations in eight surface and intermediate ocean basins attributed to various sources.
DOI: http://dx.doi.org/10.7554/eLife.00411.016 As mentioned above, we observe an 'arc-like' density in contact with domain 1 of apo-RF3 in the RC-RF1RF3 termination intermediate which we attribute to L12-CTD.
The jack pine attributes are intermediate between those of the other two plots.
Two additional cases of unilateral intermediate and panuveitis were attributed to HHV-6; however, other pathogens were also detected in the ocular fluids [6, 7].
The presence of PL thermal quenching at intermediate temperatures has been attributed to the loss of carriers within the barriers during the relaxation path[9, 10].
