Like in any marketplace, including the e-commerce paradigm, the CCM proposed herein also has four essential elements, namely buyers, sellers, intermediaries and interaction mechanisms [33].
We identified matches in databases of putative direct interactions (yeast two-hybrid) and indirect interactions (affinity purifications, yeast two-hybrid interactions with one intermediary protein and genetic interactions) in Drosophila, as well as interactions between the orthologous proteins in other species.
Betweenness centrality: It measures the position of a node and is defined as the number of times a node connects pairs of other nodes who otherwise would not be able to reach one another and plays the role of intermediary in the interaction between the other nodes.
Opportunities for linking research to action can be found in improving users' capabilities to absorb several kinds of knowledge from several sources in order to resolve specific issues at hand (i.e., form the right knowledge networks) and in improving producers' skills to connect and interact with users and intermediaries who facilitate interaction.
The interactions and relations of exchange between the helices are managed through this intermediary: "When there is interaction and interrelationship among the spheres, it is expected to take place across strongly defended boundaries and preferably through an intermediary" (Etzkowitz 2003: 306, emphasis added).
We present a conceptual framework for the analysis of demand articulation processes inside intermediary organisations, and in interaction with other stakeholders.
The REST approach aims to support distributed hypermedia systems that scale to Internet size, with general interfaces and intermediary components that reduce interaction latency [ 11].
In fact, α7 subunit of the nAChR has been identified as a meaningful intermediary of nicotine's interaction with the stress axis and human disease [ 36], among others.
A study about the process of collaboration between NTP and hospitals in Yogyakarta, Indonesia, reveals that partnership can be established if it begins with an intensive process of interaction including intermediary actors (i.e., persons approaching the private hospital and advocating the partnership program) for approaching the NTP and the hospital [ 16].
It must to be remembered that the gene interactions identified in our network does not mean that they are direct molecular interactions and intermediary molecules might account for such effect.
