These interlocked systems generally consist of an electron-rich and an electron-deficient portion held together by non-covalent bonds.
Therefore, the study of novel DNA-based interlocked systems is of interest for nanotechnology, synthetic biology, supramolecular chemistry, biotechnology, and for sensing purposes.
This, in turn, is divided into subsections focussed on extended pyridine derivatives, and interactions in both solution (examining both host guest complexes and interlocked systems) and the solid state (crystal engineering).
I hope to further understand these interlocked systems of natural and social capital, and believe this is possible; by combining disciplines, working at many scales, forging partnerships, and looking back in order to understand future options.
Fluorescence spectroscopy has been widely used to detect shuttling processes in interlocked systems, particularly in rotaxanes.
Interlocked systems are useful in such dye-displacement assays, as the displaced dye typically diffuses away preventing reversibility, whereas the stable rotaxane structure allows reversibility and reusability.
These films constitute not only an addition to the few surface-confined tethered interlocked systems but, to the best of our knowledge, are also the first incorporating a redox-active osmium II) bipy reporter motif.
The precision and effectiveness with which suitable templates and/or noncovalent interactions can arrange building blocks has also enabled the synthesis of intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean rings, and a Star of David catenane.
In terms of engineering design concept, the circadian clock is suggested to not only evolve an interlocked feedback system but also intensively design kinetic parameters for further enhanced robustness.
