Sentence examples for interim modifications from inspiring English sources
Flexible MAMS designs allow for interim modifications to the design plan without compromising error rates.
In the interim, this intermediate modification, with a higher dose of oxaliplatin and an entirely outpatient regimen, appears active, convenient and safe.
The sample size re-estimation (SSR) adaptive design allows interim analyses and resultant modifications of the ongoing trial to preserve or increase power.
Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made.
However, such treatment modification using the interim metabolic response remains controversial, and its clinical use is not permitted, except in clinical trials.
Generally, the QMRP writes the Interim Staffing with suggested changes or modifications, sends it to the IDTeam for review and signatures.
Flexible designs for clinical trials permit mid-trial design modifications, which are based on interim information from inside or outside the trial while meeting (regulatory) requirements for the control of the type I error rate.
After the completion of Round 1 (n = 8 interviews), an interim analysis was conducted using the criteria listed, and modifications were made accordingly and retested during Round 2 interviews (n = 17 interviews) before finalizing the instrument.
We evaluated the effectiveness of interim monitoring of HIV infection rates and on-going modification of recruitment strategies to enroll women at higher risk of HIV in the Cellulose Sulfate Phase III study in Nigeria.
[ 1] It is unclear to what extent protocol modifications have been made in trials based on interim analyses, and more specifically as a result of recommendations by DMCs.
Different epoxy based adhesives were tried out and surface modifications like grinding and degreasing were applied to react on the interim results of the campaign.
