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We imputed missing values for all baseline and interim exposure variables using multiple imputation (N = 5).
These results support the hypothesis that PBB exposure was a recent interim exposure whereas DDE exposure has been cumulative throughout a person's lifetime.
Such interim precautionary measures could include guidelines for conducting work-place exposure assessments, implementing engineering controls, designating work practices, and developing process or industry interim exposure limits as core elements.
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These findings are consistent with recent, interim PBB exposure, perhaps from a common dietary source for families.
In the interim, serological evidence of exposure should be based on assays with known sensitivity and specificity against culture-confirmed melioidosis.
"The levy will only be introduced in two years' time, with the clear intention that companies reformulate their products in the interim to reduce or eliminate exposure to the levy," she said.
It is essential to ensure that the appropriate PK/PD target concentration is achieved promptly within the first 24 hours of antimicrobial therapy rather than delay this goal until steady state because the suboptimal exposure in the interim can potentially promote resistant bacterial strains [6].
In the interim, however, serologic evidence of exposure should be based on assays with known sensitivity and specificity against culture-confirmed melioidosis, and, to our understanding, the IHA is the best test for identifying melioidosis cases.
The dose for manganese was found to be higher in all the samples as compared to the interim guidance value for chronic exposure for manganese of 0.160 mg/kg/day[ 22, 45], whereas the dose for zinc was found to be lower than the oral MRLs for chronic exposure of 0.300 mg/kg/day[ 23, 45] in all of the samples analysed.
It is essential to ensure that the appropriate PK/PD target concentration is achieved promptly within the first 24 hours of antimicrobial therapy rather than delay this goal until steady state because the suboptimal exposure in the interim can potentially promote resistant bacterial strains [ 6].
Inhalation of airborne nanoparticles is a major exposure scenario30, and an interim report on risk assessment of C60 proposed the acceptable exposure concentration of 0.8 mg/m3 as respirable dust in working environments31.
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