Restaging consisted of interim examinations during ongoing therapy (n = 14), examination after end of treatment (n = 19), and surveillance (n = 35).
A subchronic toxicity study in rats (Dorman et al. 2008) with interim examinations showed that effects were observed already at day 4; therefore, there is no need to include time extrapolation in the calculation.
The use of the incidence density permitted to include the results of interim examinations which would be lost if had been adopted the caries increment as an effect measure [ 26].
If so, we hypothesized that interim testing of the medical students results in a higher formal examination score.
The follow-up consisted of interim history, physical examination, haematologic studies, carcinoembryonic antigen levels and diagnostic imaging (chest X-ray, abdominal ultrasonography) every 4 months in the first year, and every 6 months in the second through fifth years.
The protocol consisted of interim history, physical examination, haematology and blood chemistry panels including tests for CEA and CA19-9, peverymed every 3 months for the first postoperative year and every 6 months thereafter.
The High Court will then further consider Mr Miranda's application for an interim injunction to stop examination "until the legality of that seizure has been determined by this court".
The multiple-choice questions in the interim assessment and formal examination were validated both on medical content and educational quality.
An interim medical history, physical examination and the laboratory tests listed above were repeated prior to the start of each cycle of therapy.
The terms of reference for this committee includes performance of interim data analysis, periodic examination of emerging external evidence in relation to MIST, and monitoring of adverse events, compliance with the trial protocol, and progress of recruitment.
