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The user can optionally select an interfering tissue(s), where submitted genes are tolerated to show additional expression in normal individuals; for example, brain tissue could be selected by the user, as various genes that have been originally assumed to be testis-restricted are also expressed in the brain, another tissue residing in immunological privilege (13).
We selected 'testis' as tissue focus and chose 'brain' as interfering tissue, as it has been shown that various CT genes also exhibit expression in brain tissue (13).
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For each of the submitted genes, the expression profile is examined to determine the expression in the user-specified tissue focus, in possible interfering tissues, in all other healthy tissues as well as in all cancer-derived tissues.
Senescence is proposed to contribute to aging by depleting the renewal capacity of tissues and/or by interfering with tissue homeostasis and functions (Sharpless & DePinho, 2004; Campisi, 2005).
Pathological free radicals generated from inflamed and infarcted cardiac tissues interferes natural tissue repair mechanisms.
Challenges encountered have included limited specificity due to background fluorescence, interfering host tissue debris, and limited sensitivity due to rapid fading of fluorescence [ 18].
These structures, while vital in ensuring tissue continuity, do not support, and in some instances even interfere with, tissue or organ function.
Autonomous hypersecretion of prolactin is a common feature of pituitary tumours, since such growths tend to interfere (via tissue compression) with prolactin-suppressing signals from the hypothalamus.
Genetic alterations and mutations can interfere with tissue homoeostasis.
Concerns were raised that bicarbonate therapy might interfere with tissue oxidation and with the clearance or renal excretion of ketones, hence accounting for the paradoxical worsening of ketosis.
Next, we tested whether the Gateway system interfered with tissue specific expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com