In comparison, conventional antibiotic agents have treated a diverse multitude of microbes via interference with the integrity of the cell wall or membrane, hindrance DNA or RNA synthesis, or disruption of protein or amino acid synthesis, Fig. 2 [5].
Direct interference with the integrity of the VTA by 6-hydroxydopamine (6-OHDA) lesion also blocks nicotine's locomotor effects (Louis and Clarke 1998).
Several possible mechanisms have been proposed such as interference with tetherin integrity, steric interference between viral and cellular membranes and exclusion of tetherin from the region of plasma membrane from which EBOV bud.
The antimicrobial activity demonstrated by terpenes is attributed to their interference with the integrity and functioning of the cell membrane through induction of changes in membrane potential, loss of cytoplasmic material and inhibition of the respiratory chain [ 54, 55].
Consequently, interference with DNA integrity and a specific selection pressure favouring p53 loss-of-function mutations may be involved in the emergence of p53-mutated cells under nutlin-3 exposure.
It is suggested that the accumulation of Ca2+ within the cell leads to hypercontraction either as a result of poor Ca2+ -ATPase performance [ 114] or because of interference with sarcolemma integrity [ 115].
His plea for "legal personhood" is designed to ensure that chimpanzees and bonobos are free from serious interference with their bodily integrity and bodily liberty.
Thioridazine has multiple mechanisms of action, including interference with cell wall integrity, the binding to calcium transport membranes and inhibition of adherence of calcium, which may be lethal for cells [2], [19], [21].
It is unknown if POP interference with sperm chromatin integrity and sperm DNA may have health consequences in the offspring.
We have shown that indirect interference with the functional integrity of the VTA by making excitotoxic lesions in LDTg alters the effects on locomotion of repeated nicotine administration (Alderson et al. 2005).
