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However, this strategy serves as a proof of principle and indeed is the first report showing that a peptide-based protein domain interference strategy can be regarded as a potential way to interfere with RUNX1/ETO tetramerization and oncogene function.
This interference strategy should culminate in cancer cell growth suppression.
Using a RNA interference strategy, plant lines were generated with a diminished dUTPase activity as compared to the wild-type.
The role of EMMPRIN in the regulation of VEGFR-2 production in melanoma cells was investigated by inhibiting its expression using RNA interference strategy.
Our objective was to produce an interference strategy whereby the CPP would serve as a molecular decoy to accept phosphorylation by kinases known to activate YB-1 at S102 such as RSK, PKCα and AKT [21].
We have tested the function of these genes using an RNA interference strategy.
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Overall the proposed computational frameworks can help elucidate input/output relationships of signaling networks and help to guide the systematic design of interference strategies.
Furthermore, our optimal biological interference strategies are superior to those in many literatures in which the enemy is released by the fixed amount at the fixed time.
These include the development of direct inhibitors of the KRAS protein, use of RNA interference strategies, development of inhibitors which prevent localization of RAS to the plasma membrane, and pharmacologic targeting of its downstream effectors.
Outcomes of ribosomal protein loss in cultured mammalian cells and in cells in vivo have to date not been investigated in any greater detail but such studies have been facilitated by different conditional gene knock-out and RNA interference strategies.
Disruption of HAVCR1 expression, whether by gene-trap insertion or by RNA interference strategies in toxin-sensitive human and canine cell lines, led to increased resistance to ε-toxin-induced cytotoxicity.
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