Sentence examples for interference screens from inspiring English sources
Next-generation sequencing is also replacing microarrays in high-throughput RNA interference screens: one can perform genomewide screens to identify genes that interfere with the viability of cancer cells using pools of short hairpin RNAs, and the results can be deconvoluted using next-generation sequencing [ 32].
Using RNA interference screens, we identified host factors which upon knockdown sensitized infected cells for apoptosis induced by ligation of the TNF receptor (unpublished data).
Many RNA interference screens rely on the ability of an interfering RNA to rescue a cell from death caused by some cytotoxic drug.
However, further analyses such as mutation screening and functional RNA interference screens [23] are needed to identify the genes contributing to EVI1 leukemogenesis.
Recently, RNA interference screens targeting chromatin-associated proteins have revealed the existence of ESC regulations at the chromatin level that contribute to their open chromatin state and that are important for ESC properties, namely their self-renewal and their pluripotency [12], [13].
Two recent RNA interference screens have identified upstream regulators of mitophagy, albeit with limited overlap [ 118, 119].
Using a genome-wide RNA interference screening strategy, we identified cleavage and polyadenylation specificity factor (CPSF) and symplekin (SYMPK) as cofactors of the well-known splicing regulator RBFOX2.
The increased scrutiny brought on by the Cambridge Analytica debacle, Russian election interference, screen-time addiction, lack of protections against fake news and lax policy toward conspiracy theorists and dangerous content has triggered a reckoning for Facebook.
Only a single 75 100 nucleotide RNA is required to guide Cas9 to the target gene of interest, which has meant that the established infrastructure of short-hairpin RNA interference screen could be readily adapted to genome-wide knock out screens.
[video interference, screen clears, a man in a blue suit and a woman in a red dress sit on a couch on what appears to be a morning show set].
Using an RNA interference screen of candidate nucleases, a number of C. elegans genes were identified that increase TUNEL positive nuclei during embryogenesis [23].
