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This finding provides strong support for the occurrence of cellular interference in humans.
Here, we report the identification of mosaic EFNB1 mutations in every individual, confirming the suggested diagnosis and supporting the hypothesis of cellular interference in humans.
The presence of strong positive interference in humans [ 44] makes the propagation process more reliable because double recombination events within small genetic intervals (roughly ≤5 cM) are extremely rare.
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In this study, we developed lipid-based transport of a locked-nucleic-acid (LNA -modified oLNA -modifiede foligonucleotidevirus (HBV) DNA interforence in hepatitisatocytes expressing HBvirusomic DNA.
Depletion of CLASPs or CENP-E by RNA interference in human cells causes a significant and comparable reduction of kinetochore microtubule poleward flux and turnover rates and rescues spindle bipolarity in Kif2a-depleted cells.
Consistent with these findings, down-regulation of Orc1 by RNA interference in human cells favors E2F1 recruitment onto origins and induces a marked G1 arrest.
This could explain why Pds5 is a dispensable subunit of cohesin in fission yeast, and tolerates reduction by RNA interference in human cultured cells.
In agreement with these findings, inhibition of ChoK using RNA interference in human breast cancer cells was also associated with an MRS-detectable decrease in PC (Glunde et al, 2005).
We observed that expression of BNip3ΔTM and simultaneous downregulation of endogenous BNip3 by RNA interference in human HD muscle cells rescued the Δ ψm loss induced by mutant htt.
The results were concordant with the significant suppression of cell growth caused by TOPK interference in human breast cancer and colorectal cell lines (Park et al, 2006; Zhu et al, 2007).
SIRT6 depletion by RNA interference in human umbilical vein endothelial cells (HUVEC) and aortic endothelial cells reduced cell proliferation, increased the fraction of senescence-associated-β-galactosidase-positive cells, and diminished the ability of the cells to form tubule networks on Matrigel.
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