Sentence examples for interface specificity from inspiring English sources

This allows optimal alignment of interface specificity sites, without producing energetically costly conformational changes, essential for high-affinity binding.

We also find that we can computationally recapitulate specificity changes upon mutation, a key test for successful forward design of protein protein interface specificity.

Then, we use a case study in order to recall the basic concepts of the ICO formalism and the recent extensions added in order to take into account post-WIMP interfaces' specificities.

Thus, this conserved hydrophobic face may contribute universally to E. histolytica Rho/effector interfaces, while specificity is likely dictated by additional interactions.

(3) In addition to the diversity of interaction interfaces, the specificity and selectivity of CaM target activation may be achieved by variations in the target-specific dissociation and cooperatively effected dissociation constants, the order of Ca2+-CaM-target complex assembly and the number of Ca2+ ions required to bind CaM for target activation.

In the literature, many different test statistics have been used to evaluate interface predictions, including specificity, sensitivity, Matthews correlation and AUC (Area Under the Curve) (see [4] for a review).

To directly investigate contributions of each interface contact to specificity, we determined for each mutant the k2 ratio for cleavage of the SRL RNA and the nonspecific ssNA substrate.

Notably, in the structures of TRF1 and TRF2 this arm was discussed to be important for extending the DNA-binding interface by adding specificity and affinity (Court et al, 2005).

The only current method available to probe such interfaces with molecular specificity is the vibrational spectroscopy, sum frequency generation (SFG).

A new method is presented for the redesign of protein protein interfaces, resulting in specificity of the designed pair while maintaining high affinity.

Yet their distinct profile and that of surrounding residues found in the described interfaces ensure the specificity for each interaction.