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First, we generate optimal pairwise interface alignments and then use a version of the neighbor-joining algorithm to align multiple interfaces.
Backbone structure comparison methods like DaliLite can be used to generate interface alignments indirectly.
To assess whether Galinter produces valid interface alignments, we compared the results of Galinter to the alignments generated by other approaches.
CMAPi generates the most accurate interface alignments for cytokine families, one of the more challenging cases previously investigated by LTHREADER.
These improved interface alignments should enhance homology modeling and threading methods for predicting PPIs by providing a basis for generating template profiles for sequence structure alignment.
Using the Ensembl Perl application program interface, alignments of protein sequences of C. elegans, C. briggsae, C. remanei, C. brenneri, and C. japonica were retrieved (version 59, Kersey et al. 2012).
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The research findings contribute to a better understanding of nanotube-polymer interface, alignment mechanisms, and ultimately the optimal design and performance of functional nanotube - aromatic polymer nanocomposites.
Considering the interface alignment, fastening, interaction, and assembly/disassembly, mechanical structures of each interface are designed as follows: (1) Interface A supports the loading weight from the container module for bulk loads, or the platform module for packed boxes.
Meanwhile, these results also indicate that to compare protein-protein interfaces, an explicit interface alignment approach is more adequate than an approach based on backbone structure.
The method was applied to the pilot dataset [17] and compared to an interface alignment method and to a backbone structure alignment method.
Nevertheless, a thorough investigation is required on how to weight different types of non-covalent interactions for interface alignment, which will be the focus of future work.
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CEO of Professional Science Editing for Scientists @ prosciediting.com