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Interestingly, in this cell line, the induced inclusions were also present along the neuronal neurites (Fig. 1C).
Interestingly, in this cell line, which expresses a higher level of activated p38-MAPK compared with parental DU145 cells, panobinostat completely inhibited p38-MAPK basal activation.
Interestingly, in this cell line both the LCR and HBD lie in regions of open chromatin, as determined by DNAse I hypersensitivity and FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) assays, two different methods to identify nucleosome-depleted regions of the genome (supplementary fig. S4 B, Supplementary Material online).
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Interestingly, in this glial cell context, maximal induction achieved with the Aro-B reporter was three times greater than that observed with a classical estrogen-response-element reporter gene (ERE-tk-Luc).
More interestingly, R6G fluorescence in this cell abruptly dropped simultaneously with CF resurgence (arrow in Figure 5Db), strongly suggesting that R6G is also a good indicator of mitochondrial dysfunction.
Interestingly, in this context, human iNKT cells can kill macrophages that are supposed to infiltrate human neuroblastoma in a CD1d-dependent manner [51], providing a mechanistic link between neuroblastoma infiltration by iNKT cells and an improved prognosis [51].
Interestingly, in this analysis, the cisplatin-sensitive cell line 2102EP showed marked alterations in the cell cycle upon treatment with cisplatin, both alone and in combination with HP-14, whereas the cisplatin-resistant cell line 2102EP-R shonly only minimal alterations in the cell cycle.
Interestingly, in this experiment, the suppression of cell proliferation was significantly greater than in Si-Dll4-treated cells under hypoxic conditions (Fig. 5).
Interestingly, in both cell lines, the silencing of AQP1 (siRNA AQP1-1) induced a dramatically change in cell shape.
Interestingly, in other cell types, p19Arf has been implicated as a direct inhibitor of FoxM1 [ 35].
Interestingly, in human cell lines, mitoxantrone resistance has been linked to differences in plasma membrane permeability (Breuzard et al. 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com