That's really interesting, especially the involvement of the banks.
The Prdm family is hence an interesting candidate for involvement in controlling neuron class identity in the spinal cord.
Particularly interesting is the involvement of medial surface regions of both hemispheres, i.e. the SMA and the left superior dorsomedial area close to the cingulate cortex.
The NK pathway is interesting because immune involvement has been implicated in AAA [ 25, 28, 44- 47].
For instance, the role of TDP-43 is particularly interesting, given its involvement in neurodegenerative diseases including ALS.
Some other reasons which make it more interesting is its involvement biosynthesis of lucine, vsoucine and valine and these amino acids are essential for humans.
With the highest number of significantly enriched TFBS, e.g. for COUP-TF1, PPARγ, KROX, GATA-3, and LXR, TMEM135 is an interesting candidate for involvement in lineage commitment, an hypothesis that must nevertheless be validated by further studies.
With this in mind we find the high frequency (4 of 4) of anti-CRP in patients with ongoing kidney involvement interesting, given the pathogenetic implications of ICs in lupus nephritis, but extended studies on larger materials are needed.
The Map1b target is particularly interesting given its involvement in neurite outgrowth in general, and a recent report demonstrating miR-9 regulation of axonal length via Map1b regulation (Dajas-Bailador).
The expression profile of claudin-1 in non-malignant versus tumor-derived cells has made this gene an interesting candidate for involvement in tumorigenesis, namely by acting as a suppressor of mammary epithelial proliferation.
