Interesting hubs prioritized in this way then form the basis of hypotheses that can be subjected to experimental investigation.
I thought it was interesting that Girl Hub conducted a study in which they were testing what object would better improve the life of a girl living under conditions that classify her vulnerable, between an economic stove, a lamp, a reusable pad and a sewing machine.
Overall, both within pathway hubs and cross pathway hubs are interesting candidates for experimental perturbation by knockdown or knockout, such experiments could define the relationship of the hub to overall phenotype and test the importance of the detected interactions.
She posts links to stories and case studies, so her timeline acts as a kind of hub for interesting content.
In this edition of the organizational zoo series, we take a closer look at an interesting organization design case GitHub, a software company from California.
It is interesting to note that hub proteins are usually targeted, such as LCK, STAT1 and VCAN in Normal-Cirrhosis network, LCK in Cirrhosis-Dysplasia network, CDC2 and NDC80 in Dysplasia-Early HCC network and Early-Advanced network.
Hubs are interesting drug targets for cancer research [ 7] also, it has been shown that there is a relationship between number of protein interactions and its sequence conservation, and cellular properties which can be used as identifiers for separating hubs from non-hubs [ 8, 9].
On GitHub, users follow interesting developers, listen to their activities, and find new projects.
The analysis of the p53 data suggests that genes with large weights—hub genes—have interesting biological properties.
Another interesting observation is that the hub motifs in the two classes define almost completely disjoined sets (the only exception being motif 'NMYC_01'; see Table 1).
