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It is shown that the defined stent modeling is able to expand when stretched (auxetic behavior) and reveals a deformation mechanism that may be interesting for further development.
Similarly, the alternate hypothesis (Halt) specifies the response rate (ralt) and median TTP (ttp alt) that would render a drug interesting for further development, such that: Halt: r ≥ ralt or ttp ≥ ttpalt.
Higher response rates (>20 30%) must be observed in breast or small cell lung cancer to make a new drug interesting for further development, as there are numerous drugs already active in these tumour types.
Our approach represents a slight perspective shift compared with studies such as BATTLE-2 and I-SPY 2. Both these studies start with a collection of drugs that are deemed interesting for further development in NSCLC and breast cancer, respectively, and try to identify if one or more from a group of preselected biomarkers can predict for clinical benefit.
Such compound in particular seems to be interesting for further development, since carrying a 2-phenylpyrimidine moiety fused to the tetracyclic gonane structure, it is not predicted to interact with nuclear receptors, and thus it should be devoid of steroid receptor-mediated side effects.
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Thus, these novel H3-receptor antagonists are interesting leads for further development.
High throughput phenotypic screening of large commercially available libraries through two NIH programs has produced thousands of potentially interesting hits for further development as antitubercular agents.
Despite its limited relevance for most protein ligations, chelate control to achieve higher regioselectivity remains an interesting challenge for further development of this reaction.
The current evidence for these agents to treat primary SCCs is largely anecdotal, based on single case reports or very small numbers of eligible patients in open label trials with limited follow-up and generally lacking recurrence data, but is an interesting area for further development as new insights into the pathogenesis and targeted therapies emerge.
There are several interesting directions for further developments of this work.
In fact the study highlighted a novel interesting scaffold for IDO inhibition for further development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com