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Lastly, the variables of interest were assessed using retrospective, self-report measures and it therefore it could be argued that responses are unduly influenced by the current mood state of the participants.
Bivariate associations of continuous variables with the binary outcomes of interest were assessed using the Mann–Whitney U test.
The presence and absence of genes of interest were assessed using BLAST searches (tBLASTn or BLASTn) of sequences against a BLAST database of the isolate collection.
Univariate analyses of the relationships of categorical variables with outcomes of interest were assessed using a χ test or Fisher's exact test.
Behavioural variables of interest were assessed using all administrative and chart note data for the year prior to and including the index dates.
Univariate associations between each dimension of the SF-36 scale and other variables of interest were assessed using ANOVA for metric variables and a χ test for categorical variables.
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The test-retest reliability (TRR) of the unadjusted SUV, SUV relative to cerebellar grey matter (SUVRC) and SUV normalised to whole brain activity (SUVRWB) in nine cortical and limbic regions of interest was assessed using the absolute variability and the intraclass correlation coefficient.
Normality of variables of interest was assessed using Shapiro Wilk tests.
The validity of the diagnoses of interest was assessed using predefined criteria.
Their statistical association with various factors of interest was assessed using a log-rank test.
Linkage disequilibrium (LD) between SNPs of interest was assessed using LD information from the 1000 Genomes Project within HaploReg v2.
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