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Lack of statistical independence among species for the traits of interest was tested using the method of phylogenetically independent contrasts [ 19] as implemented in the CAIC program [ 59].
The effect on other variables of interest was tested using Student's test for all continuous variables and Fisher's exact test for categorical variable.
The normality of the distribution of VOR gain changes for each training condition at each time point of interest was tested using the Shapiro Wilk normality test (Graphpad Prism).
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Differences between groups of interest were tested using Fisher's exact tests.
Bivariate associations of categorical variables with the outcomes of interest were tested using the Chi-square test or Fisher's exact test, as appropriate.
Pathways of interest were tested using a Mann-Whitney U test to show if they were over-represented for each trait.
To account for those possible confounding variables, they were incorporated into the PLSR model and associations of interest were tested using reduced models.
Regions of interest were tested using a UMIS 2000 nanoindentation system (CSIRO, Sydney, Australia) using a 5 μm radius spherical geometry diamond indenter tip to a maximum load of 15 mN.
Differences between the two TV strategies for the parameters of interest were tested using an analysis of variance adjusted for their baseline value (value of the parameter before application of each ventilation strategy), with the model thus containing a term for patient, ventilation strategy, and baseline value.
Significance between groups was tested using post-hoc Tukey's HSD tests between conditions of interest.
Association between categorical variables and the main outcome of interest, TST positivity, were tested using the Chi-squared test or Fisher exact test.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com