Sentence examples for interest knockout from inspiring English sources

Of interest, knockout mice for Wfdc21 (Wfdc21 tm1areOMP)Wtsi ) are now available by embryo resuscitation through the KOMP project (Project ID: CSD49368) and would serve as a highly useful system in which to address the role of Wdnm1-like  in DC cell maturation in mice.

Of interest, triple knockout of RIPK3, FLIP and FADD rescue the normal phenotype (cell survival).

Of interest, PI3Kγ knockout cardiomyocytes showed a higher contractility, and PI3Kγ was shown to act as a negative regulator of contractility [ 170].

It is of some interest that p53 knockout mice develop thymic lymphomas.

8, 10 Of interest, in CAV3 knockout mice, progressive cardiac hypertrophy/cardiomyopathy is observed, 11 and in HEK293 cell lines mutant CAV3 exhibits a two- to threefold increase in late Na+ current similar to that seen in LQT3-associated SCN5A mutations.

Of interest, Ku p70-knockout mice have increased rates of primary mouse ear fibroblast transformation [ 24], and embryonic fibroblasts from Ku 80-knockout mice have a prolonged G2 phase after H2O2 treatment [ 5, 25].

Transcription activator-like effector nucleases (TALENs) are facile and potent tools used to modify a gene of interest for targeted gene knockout.

The genetic approaches examine the consequences of manipulating the genes of interest by targeted gene knockout, or alteration of expression levels or gene protein product function.

It is of interest that in Prok2 knockout mice asymmetric OB malformation was reported in approximately 50% of the mice (Ng et al., 2005), whereas we and others (Matsumoto et al., 2006) found symmetrical OB malformation in all of our Prokr2 null mice.

We theorized because of these properties we could use the vvd promoter as a tool to drive expression of other endogenous Neurospora proteins as well as exogenous proteins and moreover, by expressing our gene of interest in a vvd knockout background, we could further increase expression from the vvd promoter (Heintzen et al. 2001).

> Before ordering a mouse line produced from IKMC resources, a researcher may be interested if other knockouts of the same gene have previously been generated and phenotyped.