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Poor and suboptimal therapeutic outcomes with single anticancer drugs have led to a keen interest in combination chemotherapy.
Probably, we see rather high activity of DFT research for many actinides and polonium because of industrial interest in combination with interest in their radioactive decay.
Using these chelators for coordination of 44Sc would be of interest in combination with radiopharmaceuticals where only the NOTA -or NODAGA-derivatized species are available for clinical studies, as is the case for NODAGA-RGD: a peptide which is currently employed in clinical trials when labeled with 68Ga.
16 Hence, there is a growing interest in combination drug therapies, which could more effectively overcome endogenous compensatory mechanisms than treatments working via a single mechanism.
Using immunofluorescence for the protein of interest, in combination with other fluorescent markers for particular cell landmarks (e.g., DNA), allows for more precise protein localization.
Polyphenol compounds are of particular interest in combination therapies because they can be readily activated by oxidases overexpressed in many tumors [ 7, 8].
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They had thought that the qualities of granny's necklace would be alive with imaginative and creative possibilities for Luci's already established interest in combinations of colour and pattern.
This finding has stimulated interest in combinations of voriconazole and terbinafine (26 ), voriconazole and echinocandin (36 ), or polyene and echinocandin (36 ).
This review illustrates the pivotal role of metabolomics for the synthetic microbiology of secondary metabolism, including its crucial role in novel compound discovery in microbes, the examination of side products of engineered metabolic pathways, as well as the identification of major bottlenecks for the overproduction of compounds of interest, especially in combination with metabolic modeling.
Therefore, in many studies in this inventory, questionnaires were used to enquire about the exposure of interest, occasionally in combination with environmental measurements (water contamination).
In our laboratory we have been interested in combinations of PS-341 with anthracyclines, given the prominent role of the latter group of agents in breast cancer therapy.
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