Why the big interest from Atomico — the same firm that's raising a $286 million fund and was just voted "The VC of the Year" at Europe's tech startup awards?
Our interest springs from the same source as our passion for lurid celebrity gossip that dominates tabloids.
In addition, A. vulgare is of particular interest because individuals from the same population are mono-infected (to date, no naturally co-infected individuals have been observed) by one of three different strains of Wolbachia (wVulM, wVulC and wVulP) [27], [28].
Controls with no personal history of cancer, selected with diagnoses considered unrelated to the exposures of interest, were selected from the same hospitals and matched with cases for age, sex and race/ethnicity.
For multiple rare mutations expected to affect phenotypic traits of interest, grouping variants from the same genes, pathways, and segmental conserved regions has provided promising results (Bodmer and Bonilla 2008; Cohen et al. 2004; Nejentsev et al. 2009).
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All from a childhood interest in the same bugs and reptiles and small mammals that a New Jersey kid might find today.
This can be achieved by integrating the reporter gene (mannanase) and the gene of interest under the same promoter, from where they can be expressed proportionally.
