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The design of vesicles that become unstable at an easily tuned value of pH is of great interest for targeted drug delivery.
A 12-lipoxygenase in zebra fish (zf12-LOX) was found to be required for normal embryonic development and LOXs are of great interest for targeted drug designing.
Human lipoxygenases (LOXs) and their metabolites have a great impact on human homeostasis and are of interest for targeted drug design.
Yet, these regions could be drivers of species-specific evolution and thus of interest for targeted functional analyses.
However, for genetically highly complex traits, it is likely to be necessary to delimit the genomic region carrying the new mutation of interest for targeted resequencing.
In this regard, mechanisms leading to the increased synthesis of extracellular matrix proteins in fibroblasts are of particular interest for targeted therapies.
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Biodegradable nanoparticles (NPs) have gained tremendous interest for targeting chemotherapeutic drugs to the tumor environment.
These agents are of particular interest for targeting hormone receptor negative breast epithelial proliferations or dysplasia (Mehta et al, 2000).
For a receptor to be of interest for targeting, similar expression in both the primary tumors and the disseminated lesions are required.
For a receptor to be of interest for targeting nuclides therapy, similar expression in both the primary tumors and the disseminated lesions are required.
As suggested previously [ 24], the THK compounds family (such as THK523 and now THK5117) could share some binding properties with FDDNP; all of them are of interest for targeting tau pathology.
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