Thus, future research will have to focus on the interdependent network of post-translational modifications of p53.
Furthermore, as PTMs are interdependent, the nucleosomal context of modifications plays a crucial role in regulating chromatin structure [ 1].
The main epigenetic phenomena in mammals are DNA methylation and histone modifications, which are tightly interdependent.
Are these two modifications mutually exclusive or interdependent?
It is thus likely that DNA methylation and the H3K9me2 modification are not always interdependent, and that they can be regulated independently in the LoD regions of male germ cells and cancer cells.
The first is the "histone code" model which states that histone tail modification, occurring in sequential, interdependent layers, specifically alters the affinity for various chromatin associated proteins in a way that influences downstream function.
We showed in McLean and Postlewaite (2014) that when agents are informationally small, there exist small modifications to VCG mechanisms in interdependent value problems that restore incentive compatibility.
Individual modifications of histones may be interdependent, with methylation of certain lysine residues blocking or enhancing the addition of acetyl groups nearby [ 8, 9].
The epigenome comprises interconnected, interdependent heritable processes (including DNA methylation, histone modifications, and non-coding RNAs) that regulate gene expression in response to environmental influences.
Several interdependent processes are currently classified as epigenetic, such as DNA methylation, nuclear positioning and covalent modifications of histone proteins, interaction with non-coding RNA species, and higher order organization of nucleic acid in the nucleus.
In addition, the cell has evolved several interdependent processes capable of enhancing the accessibility of excision repair enzymes to DNA lesions in nucleosomes, including post-translational modification of histones, ATP-dependent chromatin remodeling and interchange of histone variants in nucleosomes.
