Potential interdependent alterations and deranged pathways were identified and copy number changes were correlated to stage, differentiation and survival.
The two active sites are partially interdependent, since alterations to one site affect the second.
Further, these modality specific maps are highly interdependent and any alterations of the visual or auditory modality during the development have a great impact on the spatial representation of the spared modality in the superior colliculus [46], [47], [48]; the mechanisms of sound localization are supported by a large network of subcortical and cortical regions [49], [50], [51].
Changes (e.g., after drug treatment) or differences of the respective ratios (e.g., between populations) are taken as correlates for alterations in the two interdependent systems as shown for pravastatin.
To investigate whether P1-mediated nuclear anchoring of IF networks and phenotypic alterations of myonuclei were interdependent, we subjected teased extensor digitorum longus (EDL) muscle fibers isolated from wild-type, P1-KO, P1b-KO, MCK-Cre/cKO and desmin-null mice to comparative analyses of nuclear and IF network parameters.
In interdependent and therefore tightly coupled systems, changes to one systems component will require alteration elsewhere in the system, therefore impairing the capacity of these systems to be changed.
It has been well established that the pathogenesis of rheumatoid arthritis (RA) comprises three distinct but interdependent phenomena: the hyperplasia of synovial tissue, chronic inflammation (both local and systemic), and alterations in the immune response, including changes in the T-cell repertoire and the production of autoantibodies [ 1].
The notion of interdependent mRNA-miRNA transcriptional profiles controlling the Rasless phenotype is also supported by the observation that most transcriptional alterations of these miRs were predicted, with highly significant p-values (Table 1), by Genecodis analysis of the list of differentially expressed mRNAs of Rasless cells (Additional file 1: Table S1).
"It's being interdependent".
